研究内容｜熊本大学連携大学院｜国立病院機構熊本医療センター
研究内容
救急搬送患者の在院死亡率予測法の開発
敗血症性播種性血管内凝固症における予後予測因子としてのProtein C活性の検討
重症感染症では高率に播種性血管内凝固(Disseminated intravascular coagulation, DIC）を合併し、その予後は不良である。重症感染症患者の予後予測因子としてはAPACHE IIスコアが開発されているが、スコア算出は煩雑であり、より簡便な予測因子が望まれる。近年、Antithrombin (AT)値が重症感染症において有意に低下し、生命予後の予測因子になることは広く知られるようになり、APACHEIIスコアの代替指標となり得ることが期待されている。我々は、感染性DICではProtein C (PC)値もAT値同様に低下することに着目した。本研究では、感染性DIC患者においてPC値が予後予測因子となり得るか検討する。
救急外来における向精神薬大量服薬患者の予後予測因子の検討
救急外来には、向精神薬の大量服薬患者が多数搬送されてくる。これらの患者の多くは年齢が若く、軽症であり、入院を要しないことが多いが、中には誤嚥性肺炎や薬物中毒症状を呈し、ICU等で入院管理を要することもある。救急外来で、これら患者の重症度を簡便に見分ける方法はなく、これらの患者の入院振り分けは担当医の勘に頼っているのが現状である。本研究の目的は、救急車のプレホスピタルレコードを用いて患者のバイタルサインや意識状態から、大量向精神薬服薬患者の予後を予測する方法を開発することにある。
心停止蘇生後のストレス反応・炎症反応・血糖値の検討
心停止後蘇生患者で、蘇生直後のストレス反応マーカー及び血糖値と生命予後の関係を調査し、予後因子を明らかにする。
妊娠糖尿病の病態解析
妊娠糖尿病はたとえ糖尿病の程度が軽度であっても巨大児など、周産期の様々な合併症のリスクとなる。また一方、妊娠糖尿病と診断された女性は将来の2型糖尿病発症のハイリスク群でもある。本研究では、妊娠糖尿病診断の時点でインスリン治療の必要性および将来の2型糖尿病発症について、予測が可能であるか検討する。
抗GAD抗体陽性妊娠糖尿病患者のフォローアップ研究
妊娠糖尿病患者の6.2%(24/385例)で抗GAD抗体などの膵島関連自己抗体が陽性であること、その中の50%（12例）で1型糖尿病が発症したこと、またその発症時期は5年以内が91.6%であったことが海外から報告された。抗GAD抗体陽性妊娠糖尿病患者は１型糖尿病発症の高リスク群と考えられるが、本邦における同様の報告は見当たらない。本研究は、抗GAD抗体陽性娠糖尿病患者の１型糖尿病発症率および糖代謝病態の変化を調査する目的とした、当科受診歴のある妊娠糖尿病患者を対象とした前向き観察研究である。
研究業績
Comparative study on quick sequential organ failure assessment, systemic inflammatory response syndrome and the shock index in prehospital emergency patients: single-site retrospective study
Acute Medicine & Surgery. 2019;6:131-7
One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance
Nishikawa T, Ono K, Hashimoto S, Kinoshita H, Watanabe T, Araki H, Otsu K, Sakamoto W, Harada M, Toyonaga T, Kawakami S, Fukuda J, Haga Y, Kukidome D, Takahashi T, Araki E
Journal of diabetes investigation. 2018;9(6):1370-7
Impaired balance is related to the progression of diabetic complications in both young and older adults
Kukidome D, Nishikawa T, Sato M, Nishi Y, Shimamura R, Kawashima J, Shimoda S, Mizuta H, Araki E
J Diabetes Complications. 2017;31(8):1275-82
Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells
Kajihara N, Kukidome D, Sada K, Motoshima H, Furukawa N, Matsumura T, Nishikawa T, Araki E
Journal of diabetes investigation. 2017
New glycemic targets for patients with diabetes from the Japan Diabetes Society
Araki E, Haneda M, Kasuga M, Nishikawa T, Kondo T, Ueki K, Kadowaki T
Journal of diabetes investigation. 2017;8(1):123-5
Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1
Sada K, Nishikawa T, Kukidome D, Yoshinaga T, Kajihara N, Sonoda K, Senokuchi T, Motoshima H, Matsumura T, Araki E
PloS one. 2016;11(7):e0158619
Involvement of advanced glycation end-products in ‘hyperglycemic memory’
Nishikawa T, Araki E
Journal of diabetes investigation. 2016;7(3):297-9
Measurement of small fibre pain threshold values for the early detection of diabetic polyneuropathy
Kukidome D, Nishikawa T, Sato M, Igata M, Kawashima J, Shimoda S, Matsui K, Obayashi K, Ando Y, Araki E
Diabetic medicine : a journal of the British Diabetic Association. 2016;33(1):62-9
Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma
Igata M, Tsuruzoe K, Kawashima J, Kukidome D, Kondo T, Motoshima H, Shimoda S, Furukawa N, Nishikawa T, Miyamura N, Araki E
Endocrinology, diabetes & metabolism case reports. 2016;2016:160003
Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice
Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E
Journal of clinical biochemistry and nutrition. 2016;59(3):207-14
New glycemic targets for patients with diabetes from the Japan Diabetes Society
Araki E, Haneda M, Kasuga M, Nishikawa T, Kondo T, Ueki K, Kadowaki T
Diabetology International. 2016;7(4):327–30
Mitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy
Nishikawa T, Brownlee M, Araki E
Journal of diabetes investigation. 2015;6(2):137-9
Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-gamma activation
Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E
Biochem Biophys Res Commun. 2015;457(1):23-30
Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room
Takeda Y, Kawashima T, Kiyota K, Oda S, Morimoto N, Kobata H, Isobe H, Honda M, Fujimi S, Onda J, I S, Sakamoto T, Ishikawa M, Nakano H, Sadamitsu D, Kishikawa M, Kinoshita K, Yokoyama T, Harada M, Kitaura M, Ichihara K, Hashimoto H, Tsuji H, Yorifuji T, Nagano O, Katayama H, Ujike Y, Morita K
Resuscitation 2014;85:1647–53
Prevalence of metabolic syndrome in stroke patients: a prospective multicenter study in Japan
Takahashi T, Harada M, Kikuno T, Ujihara M, Sadamitsu D, Manabe Y, Yasaka M, Takayama H, Kobori S, Araki E
Acute Medicine & Surgery 2014;1:17–22
What is the role of soluble cytokine receptors in adult T-cell leukemia/lymphoma?
Pornkuna R, Nishioka C, Takemoto S
Journal of Hematology and Thromboembolic Disease, published online. doi: 10.1111/bjh.13338
Effect of blood transfusion on supportive therapy of elderly patients at Kumamoto, Japan as compared with Khon Kaen, Thailand
Pornkuna R, Wongkhantee S, Jinathongthai S, Shimogawa S, Takemoto S
Journal of Hematology and Thromboembolic Disease 2014; 2:152–156
A lack of cellular senescence, formation of microenvironment, and role of soluble CD30 in development of adult T-cell leukemia/lymphoma
Pornkuna R, Takemoto S
Journal of Hematology and Thromboembolic Disease 2014；2:151–156
Clinical Value of Serum Soluble CD30 Levels in Adult T-Cell Leukemia/Lymphoma
Pornkuna R, Takemoto S, Hidaka M, Kawano F, Haga Y
Journal of Hematology and Thromboembolic Disease 2014;2:167–175
Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive ATL: a randomized phase II study
Ishida T, Jo T, Takemoto S, Suzushima H, Uozumi K, Yamamoto K, Uike N, Saburi Y, Nosaka K, Utsunomiya A, Tobinai K, Fujiwara H, Ishitsuka K, Yoshida S, Taira N, Moriuchi Y, Imada K, Miyamoto T, Akinaga S, Tomonaga M, Ueda R
Br J Haematol published online. doi: 10.1111/bjh.13338
Serum soluble CD25 and CD30 levels as a biomarker in adult T-cell leukemia/lymphoma patients undergoing allogeneic hematopoietic stem cell transplantation
Takemoto S
Journal of Hematology and Thromboembolic Disease 2014;3:182–184
Human Retroviruses and Soluble CD30 Levels of Patients
Takemoto S
Journal of Cell Science & Therapy 2014;5:184–186
Soluble CD30 and peripheral blood or pulmonary involvement of adult T-cell leukemia/lymphoma
Takemoto S, Pornkuna R
Integrative Cancer Science and Therapeutics 2014;1:10–11
Mutualism among HTLV-1-infected different type of cells or among other virus-infected cells
Takemoto S, Pornkuna R
Journal of Hematology and Thromboembolic Disease 2014;2:164–166
CD30+ Cells in Lung of Indolent Type Adult T-Cell Leukemia/Lymphoma and Elevated Serum Levels of Soluble CD30 Associated with Acute Crisis and Relapse of Disease
Takemoto S, Morimatsu Y, Pornkuna R, Murayama T, Kawano F
Journal of Leukemia 2014;2:166–171
The EPOS-CC score: an integration of independent, tumor- and patient-associated risk factors to predict 5-year overall survival following colorectal cancer surgery
Haga Y, Ikejiri K, Wada Y, Ikenaga M, Koike S, Nakamura S, Koseki M
Wolrd J Surg, published online. DOI 10.1007/s00268-015-2962-3
Preliminary study of surgical audit for overall survival following gastric cancer resection
Haga Y, Ikejiri K, Wada Y, Ikenaga M, Takeuchi H
Gastric Cancer 2015;18:138–146
Value of general surgical risk models for predicting postoperative morbidity and mortality in pancreatic resections for pancreatobiliary carcinomas
Haga Y, Wada Y, Saitoh T, Takeuchi H, Ikejiri K, Ikenaga M
J Hepatobiliary Pancreat Sci 2014;21:599–606
Evaluation of modified Estimation of Physiologic Ability and Surgical Stress in patients undergoing surgery for choledochocystolithiasis
Haga Y, Wada Y, Takeuchi H, Furuya T
World J Surg 2014;38:1177–1183
The development and validation of the Calculation of post-Operative Risk in Emergency Surgery (CORES) model
Miyazaki N, Haga Y, Matsukawa H, Ishimura T, Fujita M, Ejima T, Tanimoto H
Surgery Today 2014;44:1443–1456
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patienta With Severe Sepsis
Piere-Francois SM, Francois B, Takahashi T, et al
JAMA 2013;309:1154–1162
Risk factors for catheter-related bloodstream infections in adult hospitalized patients - Multicenter cohort study
Haga Y, Miyanari N, Takahashi T, Koike S, Kobayashi R, Mizusawa H, Nakamichi C, Goto M
Scand J Infect Dis. 2013;45:773–9
Quality of Gastric Cancer Care in Designated Cancer Care Hospitals in Japan
Higashi T, Nakamura F, Haga Y, et al
Int J Qual Health Care. 2013;25:418–28
Value of general surgical risk models for predicting postoperative liver failure and mortality following liver surgery
Haga Y, Ikejiri K, Takeuchi H, Ikenaga M, Wada Y
J Surg Oncol. 2012;106:898–904
Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study
Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S, Saburi Y, Miyamoto T, Takemoto S, Suzushima H, Tsukasaki K, Nosaka K, Fujiwara H, Ishitsuka K, Inagaki H, Ogura M, Akinaga S, Tomonaga M, Tobinai K, Ueda R
J Clin Oncol. 2012;30:837–842
Evaluation of modified Estimation of Physiologic Ability and Surgical Stress (mE-PASS) in gastric carcinoma surgery
Haga Y, Wada Y, Takeuchi H, Ikejiri K, Ikenaga M, Kimura O
Gastric Cancer. 2012;15:7–14
Evaluation of modified Estimation of Physiologic Ability and Surgical Stress (mE-PSS) in colorectal carcinoma surgery
Haga Y, Wada Y, Ikenaga M, Takeuchi H, Ikejiri K
Dis Colon Rectum. 2011;54:1293–1300
Evaluation of Estimation of Physiologic Ability and Surgical Stress to predict in-hospital mortality in cardiac surgery
Kotera A, Haga Y, Kei J, Okamoto M, Seo K
J Anesth. 2011;25:481–91
Prediction of anastomotic leak and its prognosis in digestive surgery
Haga Y, Wada Y, Takeuchi H, Ikejiri K, Ikenaga M
World J Surg 2011;35:716–722
A multicenter prospective study of surgical audit systems
Haga Y, Ikejiri K, Wada Y, Takahashi T, Ikenaga M, Akiyama N, Koike S, Koseki M, Saitoh T
Ann Surg 2011;253:194–201
Timing of the appearance of early hypodense computed tomography signs in patients with middle cerebral artery/internal carotid artery embolism
Takahashi T, Yamada S, Shimizu C, Kitada M, Sakurai T, Hashimoto S, Harada M
Journal of Japanese Association for Acute Medicine 2010;21:159–164
Maximal sterile barrier precautions do not reduce catheter-related blood stream infections in general surgery units: a multi-institutional randomized controlled trial
Ishikawa Y, Kiyama T, Haga Y, Ishikawa M, Takeuchi H, Kimura O, Harihara Y, Sunouchi K, Furuya T, Kimura M
Ann Surg, 2010;251:620–623
Efficacy of vasopressin administration in the resuscitation of out-of-hospital cardiopulmonary arrest patients
Takahashi T, Harada M, Uenohara K, Kikuno T, Honma M, Koizumi M, Uchiyama H, Takahashi T, Ishikura H, Sadamitsu D, Iida H, Miyagatani K, Yamashita H, Saeki S, Takayama H, Kobori S, Kimura A
IRYO 2009;63:380–385
New prediction rule for mortality in acute mesenteric ischemia
Haga Y, Odo M, Homma M, Komiyama K, Takeda K, Koike S, Takahashi T, Hiraka K, Yamashita H, Tanakaya K
Digestion, 2009;80:104–111